Hemicholinium 3
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) [1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].
Product Specifications
CAS Number
[312-45-8]
Product Name Alternative
Hemicholinium (dibromide)
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hemicholinium-3.html
Concentration
10mM
Purity
99.85
Solubility
H2O : 33.33 mg/mL (ultrasonic)
Smiles
C[N+]1(C)CC(C2=CC=C(C3=CC=C(C4(O)C[N+](C)(C)CCO4)C=C3)C=C2)(O)OCC1.[Br-].[Br-]
Molecular Formula
C24H34Br2N2O4
Molecular Weight
574.35
Precautions
H301+H311+H331, H315, H319, H335
References & Citations
143
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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