20-HETE inhibitor-2

20-HETE inhibitor-2 is an orally active 20-HETE inhibitor. 20-HETE inhibitor-2 can inhibit the activities of CYP4F2 and CYP4A11, thereby suppressing the production of 20-HETE. 20-HETE inhibitor-2 has the effect of improving blood glucose and can be used for the research of various diseases related to 20-HETE such as obesity[1][2].

Product Specifications

CAS Number

[2992666-48-3]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/20-hete-inhibitor-2.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC(C2=CNN=C2)=CC=C1N(CC3)CCC3CN4C(CCC4)=O

Molecular Formula

C19H23FN4O

Molecular Weight

342.41

References & Citations

[1]Lee Apostle Mcdermott, et al. 20-hete formation inhibitors. US, WO2020163689. 2020-02-07.|[2]Xiong C, et al. 1,4-diheterocyclic substituted aromatic ring or aromatic heterocyclic compound and use thereof. WO2023185821A1. 2023-10-05.