GSK2163632A
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272) .
Product Specifications
CAS Number
[1123163-20-1]
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; IGF-1R; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk2163632a.html
Smiles
O=C(N)C1=C(C=CS1)NC2=C3C(NC=C3)=NC(NC4=CC5=C(C(C)(CCN5C(CN(C)C)=O)C)C=C4OC)=N2
Molecular Formula
C27H32N8O3S
Molecular Weight
548.66
References & Citations
[1]Identification and Structure−Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2
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