GSK2163632A
GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272) .
Product Specifications
CAS Number
[1123163-20-1]
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; IGF-1R; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk2163632a.html
Smiles
O=C(N)C1=C(C=CS1)NC2=C3C(NC=C3)=NC(NC4=CC5=C(C(C)(CCN5C(CN(C)C)=O)C)C=C4OC)=N2
Molecular Formula
C27H32N8O3S
Molecular Weight
548.66
References & Citations
[1]Identification and Structure−Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Rabbit anti-human Calmodulin polyclonal Antibody, HRP conjugated
Rabbit anti-human Calmodulin polyclonal Antibody, HRP conjugated
Rabbit anti-human Calmodulin polyclonal Antibody, HRP conjugated
