What is the catalog number for W146 (TFA)?

The catalog number for W146 (TFA) is HY-101395A.

What sizes are available for W146 (TFA)?

W146 (TFA) is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does W146 (TFA) come in?

W146 (TFA) is available in 6 different pack sizes.

Is W146 (TFA) in stock?

W146 (TFA) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures W146 (TFA)?

W146 (TFA) is manufactured by QuantiMol.

What is the estimated delivery time for W146 (TFA)?

Estimated delivery time for W146 (TFA) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for W146 (TFA)?

The safety data sheet for W146 (TFA) is available here: http://file.medchemexpress.com/batch_PDF/HY-101395A/W146-TFA-SDS-MedChemExpress.pdf.

W146 (TFA)

W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

Product Specifications

CAS Number

909725-62-8

UNSPSC

12352005

Target

Apoptosis; LPL Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/w146-tfa.html

Concentration

10mM

Purity

98.22

Solubility

DMSO : 20 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O.O=C(O)C(F)(F)F

Molecular Formula

C18H28F3N2O6P

Molecular Weight

456.39

References & Citations

[1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.|[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Autophagy. 2025 Apr 10:1-19.|Cancer Commun (Lond) . 2025 Jul 16.|iScience. 2024 Oct 30;27 (12) :111290.|J Nutr Biochem. 2024 Apr:126:109587.|Nat Cell Biol. 2025 Jun;27 (6) :918-930.