RU 59063

RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom[1][2].

Product Specifications

CAS Number

[155180-53-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ru-59063.html

Purity

98.61

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(C=C1C(F)(F)F)N(C2=O)C(N(C2(C)C)CCCCO)=S

Molecular Formula

C17H18F3N3O2S

Molecular Weight

385.40

Precautions

P264-P270-P330-P501

References & Citations

[1]Teutsch G, et al. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem Mol Biol. 1994 Jan;48 (1) :111-9.|[2]Van Dort ME, et al. Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3- (4-hydroxybutyl) -5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem. 2000 Aug 24;43 (17) :3344-7.