PBA-1105b
PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105[1].
Product Specifications
CAS Number
2941386-60-1
UNSPSC
12352005
Target
Autophagy; AUTOTACs; p62
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pba-1105b.html
Smiles
O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Molecular Formula
C47H64N2O10
Molecular Weight
817.02
References & Citations
[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1343075 Inquire
Recombinant Streptococcus thermophilus DNA-directed RNA polymerase subunit beta (rpoB), partial
Sign In for Pricing
View Details 
orb3157820 200 µL
Nectarine marafivirus M capsid protein Antibody PE Conjugated
Sign In for Pricing
View Details