PBA-1105b
Product Specifications
UNSPSC Description
PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105[1].
Target Antigen
Autophagy; AUTOTACs; p62
Type
Reference compound
Related Pathways
Autophagy;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pba-1105b.html
Smiles
O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Molecular Weight
817.02
References & Citations
[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161745/PBA-1105b-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161745/
Clinical Information
No Development Reported
CAS Number
2941386-60-1
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