Anti-S100 α/α Antibody

Mouse Monoclonal Antibody specific to S-100

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

S-100 protein α chain, S-100 protein subunit α, S100 calcium-binding protein A1

Gene Name

S100A1

NCBI Gene ID

UniProt

P23297

Cellular Locus

Cytoplasm, Sarcoplasmic reticulum, Mitochondrion

Host

Mouse

Reactivity

Human

Immunogen

Purified S-100 protein from human brain.

Target Antigen

Protein S100-A1

Target

S100 α/α

Clonality

Monoclonal

Isotype

IgG2a

Type

Antibody

Applications

WB, ELISA, AP

Field of Research

Neuroscience

Purification Method

Purified by Protein A affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). {PubMed:11717446, PubMed:12804600, PubMed:22399290, PubMed:23351007}.

Additionnal Information

These antibodies may be used in ELISA and Western blot (human brain): 56203, 56204, and 56206 may be used to affinity-purify S-100.Recommended pairs for sandwich ELISA: Capture Detect 56203 56204 56206 56204