Tyrphostin AG1433

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].

Product Specifications

CAS Number

[168835-90-3]

Product Name Alternative

SU1433; AG1433

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tyrphostin-ag1433.html

Concentration

10mM

Purity

99.08

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O

Molecular Formula

C16H14N2O2

Molecular Weight

266.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38 (1) :21-33.|[2]Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56 (15) :3540-5.|[3]Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3 (11-12) :752-62.|[4]Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272 (51) :32521-7.