Disoxaril

Disoxaril (WIN-51711) is a polioviruses inhibitor. Disoxaril inhibits the replication of polioviruses types 1 and 2 in cells. Disoxaril binds directly to the virion capsid proteins and inhibits viral uncoating by stabilizing the virus capsid. Disoxaril still allows the virus to enter the cell by receptor-mediated endocytosis. Disoxaril also inhibits enterovirus replication[1][2].

Product Specifications

CAS Number

[87495-31-6]

Product Name Alternative

WIN-51711

UNSPSC

12352005

Target

Enterovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/disoxaril.html

Purity

96.50

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=NOC(CCCCCCCOC2=CC=C(C3=NCCO3)C=C2)=C1

Molecular Formula

C20H26N2O3

Molecular Weight

342.43

References & Citations

[1]Zeichhardt H, et al. Inhibition of poliovirus uncoating by disoxaril (WIN 51711) . Virology. 1987 Sep;160 (1) :281-5.|[2]Nikolova I, et al. Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. Z Naturforsch C J Biosci. 2011 Nov-Dec;66 (11-12) :627-36.