2-O-Sinapoyl makisterone A
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein[1].
Product Specifications
UNSPSC
12352005
Target
COX
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-o-sinapoyl-makisterone-a.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1/C=C/C(O[C@H]2C[C@]3(C)[C@]4(CC[C@@]5([C@@](CC[C@]5(C4=CC([C@@]3(C[C@H]2O)[H])=O)O)([H])[C@@](O)([C@H](O)C[C@@H](C)C(C)(C)O)C)C)[H])=O)=C(C(OC)=C1)O
Molecular Formula
C39H56O11
Molecular Weight
700.86
References & Citations
[1]Kakumu Y, et al. Identification of Ecdysteroid Sinapate Esters with COX-2 Inhibitory Effects from Fibraurea recisa Using Molecular Networking and MS2LDA. J Nat Prod. 2023 Aug 25;86 (8) :1960-1967.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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