S- (1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate
S- (1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S- (1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1].
Product Specifications
CAS Number
[2127875-65-2]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-1-hydroxy-2-methylpropan-2-yl-methanesulfonothioate.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(SS(C)(=O)=O)(C)CO
Molecular Formula
C5H12O3S2
Molecular Weight
184.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
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