α-Ionone

α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro[1].

Product Specifications

CAS Number

[127-41-3]

Product Name Alternative

Alpha-Ionone

UNSPSC

12352211

Hazard Statement

H334

Target

Apoptosis; Hippo (MST) ; Olfactory Receptor; YAP

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/α-ionone.html

Purity

94.30

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC1=CCCC(C)(C)C1/C=C/C(C)=O

Molecular Formula

C13H20O

Molecular Weight

192.30

Precautions

H334

References & Citations

[1]Yoon YE, et al. A Food Odorant, α-Ionone, Inhibits Skin Cancer Tumorigenesis by Activation of OR10A6. Mol Nutr Food Res. 2024 Aug;68 (15) :e2400085.|[2]Ozgen U, et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules. 2010 Apr 12;15 (4) :2593-9.