α-Ionone
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro[1].
Product Specifications
CAS Number
127-41-3
Product Name Alternative
Alpha-Ionone
UNSPSC
12352211
Hazard Statement
H334
Target
Apoptosis; Hippo (MST) ; Olfactory Receptor; YAP
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α-ionone.html
Purity
94.30
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC1=CCCC(C)(C)C1/C=C/C(C)=O
Molecular Formula
C13H20O
Molecular Weight
192.30
Precautions
H334
References & Citations
[1]Yoon YE, et al. A Food Odorant, α-Ionone, Inhibits Skin Cancer Tumorigenesis by Activation of OR10A6. Mol Nutr Food Res. 2024 Aug;68 (15) :e2400085.|[2]Ozgen U, et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules. 2010 Apr 12;15 (4) :2593-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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