Moclobemide N-Oxide

Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm[1][2].

Product Specifications

CAS Number

[64544-24-7]

Product Name Alternative

Ro 12-5637

UNSPSC

12352005

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/moclobemide-n-oxide.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC[N+]1([O-])CCOCC1)C2=CC=C(Cl)C=C2

Molecular Formula

C13H17ClN2O3

Molecular Weight

284.74

References & Citations

[1]Rakic Ignjatovic A, et al. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study. Br J Clin Pharmacol. 2009 Feb;67 (2) :199-208.|[2]Geschke R, et al. Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography. J Chromatogr. 1987 Sep 4;420 (1) :111-20.