Auglurant
Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human) . Auglurant (VU0424238) has an acceptable CNS penetration[1].
Product Specifications
CAS Number
1396337-04-4
Product Name Alternative
VU0424238
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0424238.html
Purity
99.40
Solubility
DMSO : 22.73 mg/mL (ultrasonic)
Smiles
CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN=CN=C3)=C1
Molecular Formula
C16H12FN5O2
Molecular Weight
325.30
References & Citations
[1]Felts AS, et al. Discovery of N- (5-Fluoropyridin-2-yl) -6-methyl-4- (pyrimidin-5-yloxy) picolinamide (VU0424238) : A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem. 2017 Jun 22;60 (12) :5072-5085.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY400968 100 µg
ERK1 (MAPK3) (NM_002746) Human Over-expression Lysate
Sign In for Pricing
View Details 
![PE Anti-Rat CD71 Antibody[OX-26]](https://cdn.genprice.uk/products/763/68dd1494061270361e7cd68b/imageurl/an00622ud.webp)
