Auglurant
Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human) . Auglurant (VU0424238) has an acceptable CNS penetration[1].
Product Specifications
CAS Number
[1396337-04-4]
Product Name Alternative
VU0424238
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0424238.html
Purity
99.40
Solubility
DMSO : 22.73 mg/mL (ultrasonic)
Smiles
CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN=CN=C3)=C1
Molecular Formula
C16H12FN5O2
Molecular Weight
325.30
References & Citations
[1]Felts AS, et al. Discovery of N- (5-Fluoropyridin-2-yl) -6-methyl-4- (pyrimidin-5-yloxy) picolinamide (VU0424238) : A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem. 2017 Jun 22;60 (12) :5072-5085.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
Curated Selection
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