SR 57227A
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2].
Product Specifications
CAS Number
77145-61-0
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sr-57227a.html
Purity
99.76
Solubility
DMSO : 8.33 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
ClC1=NC(N2CCC(N)CC2)=CC=C1.[H]Cl
Molecular Formula
C10H15Cl2N3
Molecular Weight
248.15
Precautions
H301, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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