VCP Activator 1
VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail[1].
Product Specifications
CAS Number
3061959-30-3
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vcp-activator-1.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 300 mg/mL (ultrasonic)
Smiles
CCSC1=CC=CC=C1NC(C[C@@H](C)N2CC3=C(C=CC=C3)C2=O)=O
Molecular Formula
C20H22N2O2S
Molecular Weight
354.47
References & Citations
[1]Jones NH, et al. Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry. bioRxiv [Preprint]. 2023 Oct 2:2023.10.02.560478.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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