Carbaryl

Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide[1][2].

Product Specifications

CAS Number

[63-25-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H350, H360

Target

Apoptosis; Cholinesterase (ChE) ; Insecticide; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/carbaryl.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1=C2C=CC=CC2=CC=C1)NC

Molecular Formula

C12H11NO2

Molecular Weight

201.22

Precautions

H302, H315, H319, H335, H350, H360

References & Citations

[1]Nancy E Todd, et al. Effects of Sevin (Carbaryl Insecticide) on Early Life Stages of Zebrafish (Danio Rerio) . Ecotoxicol Environ Saf. 2002 Oct;53 (2) :267-72.|[2]Blevins RD, et al., Effects of carbaryl and dieldrin on the growth, protein content, and phospholipid content of HeLa cells. J Agric Food Chem. 1975 May-Jun;23 (3) :377-82.|[3]Schock EN, et al., The effects of carbaryl on the development of zebrafish (Danio rerio) embryos. Zebrafish. 2012 Dec;9 (4) :169-78.|[4]Muthaiah VP, et al., Neuroprotective role of naringenin on carbaryl induced neurotoxicity in mouse neuroblastoma cells. J Pharmacol Pharmacother. 2013 Jul;4 (3) :192-7.|[5]Jorsaraei SG, et al., Immunotoxicity effects of carbaryl in vivo and in vitro. Environ Toxicol Pharmacol. 2014 Nov;38 (3) :838-44.