LPA2 antagonist 2
LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM) [1].
Product Specifications
CAS Number
[36840-10-5]
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lpa2-antagonist-2.html
Purity
95.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C(NC1=CC=C(C2=CC=C(NC(/C=C/C(O)=O)=O)C=C2)C=C1)=O
Molecular Formula
C20H16N2O6
Molecular Weight
380.35
References & Citations
[1]Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16 (11) :6207-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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