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dBRD4-BD1

Product Specifications

UNSPSC Description

dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].

Target Antigen

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics;PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbrd4-bd1.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCC(NCCOCCOCCN4CCC(CC4)N5C=NC(C6=CC=C(C(F)(F)F)C=C6)=C5C7=CC=NC(OC8=CC(C(C)C)=CC=C8C)=N7)=O)=CC=C3)=O)=O

Molecular Weight

967.00

References & Citations

[1]Divakaran A, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-151593/dBRD4-BD1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-151593/dBRD4-BD1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2839318-19-1

Available Sizes

Curated Selection

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