Human Cadherin-6 / KCAD / CDH6 Protein, His Tag (HPLC verified)

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The Human Cadherin-6 will be further processed into mature form (Ser 54-Ala 615) . The protein has a calculated MW of 63.4 kDa. The protein migrates as 86-96 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

AAH00019

Expression Region

Thr 19 - Ala 615

Host

HEK293

Target

Cadherin-6

Conjugation

Unconjugated

Tag

C-6xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

85%

Bioactivity

Immobilized Human Cadherin-6, His Tag (Cat. No. CA6-H5229) at 1 μg/mL (100 μL/well) can bind Human Cadherin-6 Antibody, Mouse IgG1 with a linear range of 0.1-1 ng/mL (QC tested).