Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Bobcat339 (hydrochloride)

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].

Product Specifications

CAS Number

[2436747-44-1]

UNSPSC

12352005

Target

DNA Methyltransferase; TET Protein

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Bobcat339_hydrochloride.html

Purity

99.62

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O.Cl

Molecular Formula

C16H13Cl2N3O

Molecular Weight

334.20

References & Citations

[1]Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10 (2) :180-185.|[2]Weirath NA, et al. Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper (II) . ACS Med Chem Lett. 2022 Apr 21;13 (5) :792-798.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TET1; TET2

Citation 01

Bioelectrochemistry. 2023 Aug:152:108433.|Cancers (Basel) . 2022 Jun 16;14 (12) :2983.|Cell Death Dis. 2024 Jun 1;15 (6) :387.|Clin Epigenetics. 2024 Oct 2;16 (1) :136.|Clin Sci. 2023 Aug 31;137 (16) :1265-1283.|Environ Sci Technol. 2021 Mar 2;55 (5) :3144-3155.|J Clin Invest. 2023 Oct 16;133 (20) :e170173.|J Pharm Biomed Anal. 2021 Sep 5:203:114228.|Mol Pain. 2022 Apr;18:17448069221143671.|Nat Metab. 2025 Jul;7 (7) :1344-1357.|Neuropharmacology. 2024 Feb 15:244:109799.|Sci Total Environ. 2024 Apr 1:919:170905.|Theranostics. 2021 Jun 11;11 (16) :7640-7657.|Aquaculture. 2023: 739234.|Br J Pharmacol. 2024 Oct;181 (20) :3886-3907.|Brain Sci. 2023 Apr 10;13 (4) :644.|EMBO Mol Med. 2025 Oct;17 (10) :2809-2826.|Eur J Pharmacol. 2024 Aug 23:176931.|J Exp Clin Cancer Res. 2025 Jul 15;44 (1) :206.|Research Square Print. 2023 Mar 14.|Research Square Print. November 29th, 2022.

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FBXO4, ID (FBXO4, FBX4, F-box only protein 4) (APC)

MBS6298440-01 0.2 mL

FBXO4, ID (FBXO4, FBX4, F-box only protein 4) (APC)

Ask

FBXO4, ID (FBXO4, FBX4, F-box only protein 4) (APC)

MBS6298440-02 5x 0.2 mL

FBXO4, ID (FBXO4, FBX4, F-box only protein 4) (APC)

Ask

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

MBS723130-01 48 Well

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

Ask

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

MBS723130-02 96 Well

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

Ask

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

MBS723130-03 5x 96 Well

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

Ask

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

MBS723130-04 10x 96 Well

Mouse Cholinergic Receptor, Muscarinic 2 ELISA Kit

Ask