LY329146

LY329146, a Raloxifene (HY-13738) analog, is multidrug resistance protein (MRP1) inhibitor. LY329146 inhibits leucotriene C4 (LTC4) transport with an IC50 of 0.8 μM[1].

Product Specifications

CAS Number

[191043-78-4]

UNSPSC

12352005

Target

Leukotriene Receptor; P-glycoprotein

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly329146.html

Smiles

CS(=O)(N(C1=CC=C(C2=C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)C5=CC=C(O)C=C5S2)C=C1)S(=O)(C)=O)=O

Molecular Formula

C30H32N2O7S3

Molecular Weight

628.78

References & Citations

[1]H Sun, et al. Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models. Pharm Res. 2001 Nov;18 (11) :1542-9.