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PCSK9-IN-11

PCSK9-IN-11 (compound 5r) is a potent and orally active PCSK9 inhibitor. PCSK9-IN-11 exhibits PCSK9 transcriptional inhibitory activity in HepG2 cells, with an IC50 of 5.7 μM. PCSK9-IN-11 increases LDL receptor (LDLR) protein level. PCSK9-IN-11 can be used for atherosclerosis research[1].

Product Specifications

CAS Number

2882035-56-3

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-in-11.html

Purity

99.30

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1C)N(C)C2=C(N(CC3=CC=CC(Cl)=C3F)C(NCCO)=N2)C1=O

Molecular Formula

C16H17ClFN5O3

Molecular Weight

381.79

References & Citations

[1]Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2022 Dec 26;247:115047.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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