CSFV E2 Antibody (5D11)

Classical swine fever (CSF) remains one of the most economically important viral diseases of domestic pigs and wild boar worldwide. The causative agent is classical swine fever virus (CSFV), it is highly contagious, with high morbidity and mortality rates. CSFV is an enveloped, single-stranded RNA (+) virus. Its genome (12.3 kb in size) encodes a single polyprotein precursor (3898 aa) which is processed by host and viral proteases into mature structural and nonstructural proteins. The structural proteins include nucleocapsid protein C and three envelope glycoproteins: E0 (Erns), E1 and E2. The CSFV glycoproteins in the viral envelope and infected cells are present in the form of biologically active disulfide-bonded homo- and heterodimers. E2 is the most immunogenic viral protein and is the major target for neutralizing antibodies. Erns is the second target for neutralizing antibodies; it exists as a homodimer (molecular mass about 97 kDa) which is present in virions, on the surface of infected cells and is also secreted from the cell .