Thalidomide-NH-CH2-COOH

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937) [1].

Product Specifications

CAS Number

[927670-97-1]

UNSPSC

12352005

Hazard Statement

H301, H312, H361

Target

Apoptosis; Autophagy; Ligands for E3 Ligase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-nh-ch2-cooh.html

Purity

98.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Molecular Formula

C15H13N3O6

Molecular Weight

331.28

Precautions

H301, H312, H361

References & Citations

[1]Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14 (2) :163-170.