4-Nitrophenyl 4-guanidinobenzoate (hydrochloride)
4-Nitrophenyl 4-guanidinobenzoate (NPGB) hydrochloride is a potent sperm acrosin inhibitor, and also a trypsin substrate[1].
Product Specifications
CAS Number
19135-17-2
Product Name Alternative
NPGB (hydrochloride)
UNSPSC
12352005
Hazard Statement
H318
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/4-nitrophenyl-4-guanidinobenzoate-hydrochloride.html
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(OC1=CC=C([N+]([O-])=O)C=C1)C2=CC=C(NC(N)=N)C=C2.[H]Cl
Molecular Formula
C14H13ClN4O4
Molecular Weight
336.73
Precautions
P280-P305+P351+P338
References & Citations
[1]J M Kaminski, et al. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. J Med Chem. 1986 Apr;29 (4) :514-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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