CCI-006
Product Specifications
Product Name Alternative
8-Nitrotryptanthrin
UNSPSC Description
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].
Target Antigen
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCI-006.html
Purity
99.87
Solubility
DMSO : ≥ 83.33 mg/mL
Smiles
O=C(/C(C#N)=C/C1=CC=C(C2=CC=C(S(=O)(N)=O)C=C2)O1)OC
Molecular Weight
332.33
References & Citations
[1]Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114410/CCI-006-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114410/CCI-006-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
292053-42-0
Available Sizes
Curated Selection
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