CCI-006

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].

Product Specifications

CAS Number

[292053-42-0]

Product Name Alternative

8-Nitrotryptanthrin

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CCI-006.html

Purity

99.87

Solubility

DMSO : ≥ 83.33 mg/mL

Smiles

O=C(/C(C#N)=C/C1=CC=C(C2=CC=C(S(=O)(N)=O)C=C2)O1)OC

Molecular Formula

C15H12N2O5S

Molecular Weight

332.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.