(Rac) -Nebivolol

(Rac) -Nebivolol ((Rac) -R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2].

Product Specifications

CAS Number

[99200-09-6]

Product Name Alternative

(Rac) -R 065824

UNSPSC

12352005

Hazard Statement

H302-H315-H320-H335

Target

Adrenergic Receptor; NADPH Oxidase

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rac-nebivolol.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C2OC(C(CNCC(C3OC4=CC=C(C=C4CC3)F)O)O)CCC2=C1

Molecular Formula

C22H25F2NO4

Molecular Weight

405.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21 (3) :224-235.|[2]Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274 (3) :1067-71.|[3]Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48 (4) :677-84.