B I09
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
Product Specifications
CAS Number
[1607803-67-7]
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/B_I09.html
Purity
99.35
Solubility
DMSO : 11.11 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4
Molecular Formula
C16H17NO5
Molecular Weight
303.31
References & Citations
[1]Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57 (10) :4289-301.|[2]Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124 (6) :2585-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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