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B I09

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

Product Specifications

CAS Number

1607803-67-7

UNSPSC

12352005

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/B_I09.html

Purity

99.35

Solubility

DMSO : 11.11 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4

Molecular Formula

C16H17NO5

Molecular Weight

303.31

References & Citations

[1]Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57 (10) :4289-301.|[2]Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124 (6) :2585-98.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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