3-Hydroxy agomelatine
3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].
Product Specifications
CAS Number
[166526-99-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-hydroxy-agomelatine.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(NCCC1=C2C=C(OC)C=CC2=CC(O)=C1)=O
Molecular Formula
C15H17NO3
Molecular Weight
259.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Chagraoui A, et al. Agomelatine (S 20098) antagonizes the penile erections induced by the stimulation of 5-HT2C receptors in Wistar rats. Psychopharmacology (Berl) . 2003 Oct;170 (1) :17-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
Curated Selection
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