PF-04634817 (succinate)
PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM) . PF-0463481 succinate is safe and well-tolerated and has the potential for the study of diabetic nephropathy[3].
Product Specifications
CAS Number
2140301-98-8
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-04634817-succinate.html
Purity
99.50
Solubility
DMSO : 14.48 mg/mL (ultrasonic; warming)
Smiles
O=C(N1[C@@]2([H])C[C@@]([H])(C1)N(C3=NC=NC(C(F)(F)F)=C3)C2)[C@@]4(C[C@@H](CC4)N[C@@H]5[C@@H](COCC5)OC)C(C)C.OC(CCC(O)=O)=O
Molecular Formula
C29H42F3N5O7
Molecular Weight
629.67
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CCR2; CCR5
Available Sizes
Frequently Asked Questions
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