Hirsutanonol

Hirsutanonol ((5S) -Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae[1].

Product Specifications

CAS Number

[41137-86-4]

Product Name Alternative

(5S) -Hirsutanonol

UNSPSC

12352005

Target

COX; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/hirsutanonol.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=CC(CCC(C[C@@H](O)CCC2=CC(O)=C(O)C=C2)=O)=C1

Molecular Formula

C19H22O6

Molecular Weight

346.37

References & Citations

[1]Lee MW, et al. Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica. Biol Pharm Bull. 2000 Apr;23 (4) :517-8.|[2]Yadav D, et al. Antifilarial diarylheptanoids from Alnus nepalensis leaves growing in high altitude areas of Uttarakhand, India. Phytomedicine. 2013 Jan 15;20 (2) :124-32.