YM-31636 (free base)

YM-31636 free base is an orally active, potent and selective 5-HT3 receptor agonist with a Ki value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation[1][2].

Product Specifications

CAS Number

[159081-22-8]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ym-31636-free-base.html

Concentration

10mM

Purity

99.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(CC2=NC3=C(S2)CC4=C3C=CC=C4)=CN=CN1

Molecular Formula

C14H11N3S

Molecular Weight

253.32

References & Citations

[1]Ito H, et al. Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409 (2) :195-201.|[2]Kiso T, et al. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Eur J Pharmacol. 2001 Nov 9;431 (1) :35-41.