G-5555 (hydrochloride)

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

Product Specifications

CAS Number

[2319590-15-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/G-5555_hydrochloride.html

Purity

98.26

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O.[H]Cl

Molecular Formula

C25H26Cl2N6O3

Molecular Weight

529.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6 (12) :1241-6.|[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59 (11) :5520-41.