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G-5555 (hydrochloride)

Product Specifications

UNSPSC Description

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

Target Antigen

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/G-5555_hydrochloride.html

Purity

98.78

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)

Smiles

ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O.[H]Cl

Molecular Weight

529.42

References & Citations

[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.|[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.Endocr Relat Cancer. 2019 Aug;26(8):699-712.|Acta Pharm Sin B. 2020 Apr;10(4):603-614.|Elife. 2017 Mar 13;6:e22207. |Endocr Relat Cancer. 2019 Aug;26(8):699-712. |Exp Hematol. 2023 Sep 21;S0301-472X(23)01701-0.|PLoS One. 2024 Jul 31;19(7):e0305121.|Research Square Preprint. 2021 Apr.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-19635A/G-5555-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19635A/G-5555-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2319590-15-1

Available Sizes

Curated Selection

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