DOPE-mPEG, MW 2000

DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs) . DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner[1][2][3].

Product Specifications

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dope-mpeg-mw-2000.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(OCCOC)=O)(O)=O)=O.[n]

Molecular Weight

2000 (Average)

Precautions

H302, H315, H319, H335

References & Citations

[1]Shin J, et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol Pharm. 2012 Nov 5;9 (11) :3266-76.|[2]Su WC, et al. Pulsatile Gating of Giant Vesicles Containing Macromolecular Crowding Agents Induced by Colligative Nonideality. J Am Chem Soc. 2018 Jan 17;140 (2) :691-699.|[3]Xu H, et al. Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug. Pharm Res. 2015 Jul;32 (7) :2428-38.