ES9-17

ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC) . ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2].

Product Specifications

CAS Number

[55854-43-8]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Clathrin; Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/es9-17.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O

Molecular Formula

C10H8BrNO2S2

Molecular Weight

318.21

Precautions

H302, H312, H332

References & Citations

[1]Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15 (6) :641-649. |[2]Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113.