(S) -Oxiracetam

(S) -oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

Product Specifications

CAS Number

[88929-35-5]

Product Name Alternative

(S) - (-) -Oxiracetam; (S) -ISF2522

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-oxiracetam.html

Purity

99.56

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(CN1C(C[C@@H](C1)O)=O)N

Molecular Formula

C6H10N2O3

Molecular Weight

158.16

Precautions

H315, H319, H335

References & Citations

[1]Fan W, et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochem Int. 2018 May;115:50-60.