PPACK II (diTFA)

PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

Product Specifications

CAS Number

[649748-23-2]

UNSPSC

12352005

Target

Kallikrein

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ppack-ii-ditfa.html

Purity

97.21

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.N=C(N)NCCC[C@@H](C(CCl)=O)NC([C@@H](NC([C@H](N)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O

Molecular Formula

C29H35ClF6N6O7

Molecular Weight

729.07

References & Citations

[1]Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106 (4) :440-5.|[2]Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340 (1-2) :163-72.