BioE-1115
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM[1].
Product Specifications
CAS Number
1268863-35-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Casein Kinase; Ser/Thr Protease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bioe-1115.html
Purity
98.17
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2N=C(C3=CC=C(F)C=C3)C(N(C)C(C)C)=NC2=C1)O
Molecular Formula
C19H18FN3O2
Molecular Weight
339.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8 (1) :242-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ENDOGL1 (Nuclease EXOG, Mitochondrial, Endonuclease G-like 1, Endo G-like 1, EXOG, ENGL, ENDOGL2) (MaxLight 650)
ENDOGL1 (Nuclease EXOG, Mitochondrial, Endonuclease G-like 1, Endo G-like 1, EXOG, ENGL, ENDOGL2) (MaxLight 650)
