ANO1-IN-1
ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].
Product Specifications
CAS Number
[407587-01-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ano1-in-1.html
Purity
99.57
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
CC(C)(C(NC1=C(C2=C(S1)CC(CC2)C(C)(C)C)C(N)=O)=O)C
Molecular Formula
C18H28N2O2S
Molecular Weight
336.49
Precautions
H302, H315, H319
References & Citations
[1]Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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