Pasiniazid

Pasiniazid is a chemical complex formed by Isoniazid (HY-B0329) and Para-aminosalicylic acid in a 1:1 molar ratio. Pasiniazid is an antibacterial agent. Pasiniazid is rapidly decomposed into isoniazid and para-aminosalicylic acid in the gastrointestinal tract. Isoniazid exerts a bactericidal effect, while para-aminosalicylic acid delays the acetylation process of isoniazid. Pasiniazid has antibacterial activity against Mycobacterium tuberculosis. Pasiniazid can be used in tuberculosis research[1].

Product Specifications

CAS Number

[2066-89-9]

Product Name Alternative

Paraniazide; Pasiniazide; Isonicotinic acid hydrazide p-aminosalicylate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Pasiniazid.html

Purity

98.2

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC=C1)NN.O=C(O)C2=CC=C(N)C=C2O

Molecular Formula

C13H14N4O4

Molecular Weight

290.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Li G, et al. Cross-resistance of isoniazid, para-aminosalicylic acid and pasiniazid against isoniazid-resistant Mycobacterium tuberculosis isolates in China. J Glob Antimicrob Resist. 2020 Mar;20:275-281.