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Dienogest-13C,15N, d4

Dienogest-13C,15N, d4 (STS 557-13C,15N, d4) is the 13C, 15N and deuterium labeled isotope of Dienogest. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia[1][2].

Product Specifications

Product Name Alternative

STS 557-13C,15N, d4

UNSPSC

12352211

Target

Isotope-Labeled Compounds; Progesterone Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Smiles

C[C@@]12[C@](O)(C([2H])([2H])[13C]#[15N])C([2H])([2H])C[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3CC2)=O

Molecular Formula

C19 13CH21D4 15NO2

Molecular Weight

317.43

References & Citations

[1]Shimizu Y, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids. 2011 Jan;76 (1-2) :60-7. |[2]Katayama H, et al. Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model. Hum Reprod. 2010 Nov;25 (11) :2851-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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