FPI-1523 (sodium)
FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].
Product Specifications
CAS Number
1452459-52-7
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fpi-1523-sodium.html
Purity
99.79
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O[Na])=O)=O)=O)=O
Molecular Formula
C9H13N4NaO7S
Molecular Weight
344.27
References & Citations
[1]King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11 (4) :864-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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