FPI-1523 (sodium)

FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].

Product Specifications

CAS Number

[1452459-52-7]

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fpi-1523-sodium.html

Purity

99.79

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O[Na])=O)=O)=O)=O

Molecular Formula

C9H13N4NaO7S

Molecular Weight

344.27

References & Citations

[1]King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11 (4) :864-8.