LP-533401
Product Specifications
UNSPSC Description
LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
Target Antigen
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/LP-533401.html
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O
Molecular Weight
526.48
References & Citations
[1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16(3), 308-312 (2010).|[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L500-8.|[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124(18):2834-46.Cell Signal. 2023 Jan 26;105:110612.|iMetaOmics. 2024 Oct 14.|Life Sci. 2021 Sep 29;285:120002.|Nat Aging. 2024 Feb 6.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15849/LP-533401-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15849/LP-533401-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
945976-43-2
Available Sizes
Curated Selection
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