LP-533401

LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

Product Specifications

CAS Number

[945976-43-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/LP-533401.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O

Molecular Formula

C27H22F4N4O3

Molecular Weight

526.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16 (3), 308-312 (2010) .|[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303 (6) :L500-8.|[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124 (18) :2834-46.