VU6028418

VU6028418 is a potent, highly selective and orally bioavailable M4 mAChR antagonist with an IC50 of 4.1 nM against hM4[1].

Product Specifications

CAS Number

[2649803-05-2]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu6028418.html

Purity

99.52

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)

Smiles

FC1=CC(F)=C(F)C(C2=CC=C(N[C@H]3C[C@@](CN(CC4CCOCC4)C5)([H])[C@@]5([H])C3)N=N2)=C1

Molecular Formula

C23H27F3N4O

Molecular Weight

432.48

References & Citations

[1]Spock M, et al. Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist. ACS Med Chem Lett. 2021 Aug 2;12 (8) :1342-1349.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAChR4

Available Sizes

Curated Selection

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