Linrodostat

Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers[1][2].

Product Specifications

CAS Number

[1923833-60-6]

Product Name Alternative

BMS-986205; ONO-7701

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BMS-986205.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)C=C1)[C@H](C)[C@@](CC2)([H])CC[C@H]2C3=CC=NC4=C3C=C(F)C=C4

Molecular Formula

C24H24ClFN2O

Molecular Weight

410.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Richards T, et al. Cell based functional assays for IDO1 inhibitor screening and characterization. Oncotarget. 2018 Jul 20;9 (56) :30814-30820.|[2]Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl) : Abstract nr CT116.